PLEC1 Mouse Monoclonal Antibody
No Size Price Availability  
AMM5339-12 50ul 1500.00 In Stock
AMM5339-12 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 5339
Isotype: IgG2a Kappa Swiss Prot: Q15149
purity: Affinity purification
Background:
Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering. Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1. Plectin is also involved in the regulation of cytokeratin architecture and cell stress response, signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes.
Reactivity Human
Tested applications WB S-ELISA ELISA IF
Clonality Monoclonal Antibody
Calculated MW 400-500 kDa
Recommended Dilutions
Immunogen PLEC1 (NP_000436, 4384 aa ~ 4493 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym EBS1, EBSO, HD1, PCN, PLEC1b, PLTN
This product is for research use only, not for diagnostic or therapeutic use!

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