MST1R Mouse Monoclonal Antibody
No Size Price Availability  
AMM4486-16 50ul 1500.00 In Stock
AMM4486-16 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 4486
Isotype: IgG2a Kappa Swiss Prot: Q04912
purity: Affinity purification
Background:
Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain. Ron is initially synthesized in the cells as a single-chain, pro-Ron precursor that is cleaved into the two active chains. The α chain is completely extracellular, whereas the β chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements. Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis. The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K)/Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival. The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors.
Reactivity Human
Tested applications S-ELISA ELISA
Clonality Monoclonal Antibody
Calculated MW 170 kDa
Recommended Dilutions
Immunogen MST1R (NP_002438, 26 aa ~ 125 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym CD136, CDw136, PTK8, RON
This product is for research use only, not for diagnostic or therapeutic use!

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