ENSA Mouse Monoclonal Antibody
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AMM2029-11 50ul 1500.00 In Stock
AMM2029-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 2029
Isotype: IgG2a Kappa Swiss Prot: O43768
purity: Affinity purification
Background:
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 15 kDa
Recommended Dilutions
Immunogen ENSA (AAH00436, 1 aa ~ 121 aa) full-length recombinant protein with GST tag
Storage Store at -20°C or lower in ascites fluid. Avoid freeze/thaw cycles.
Synonym MGC4319, MGC78563, MGC8394
This product is for research use only, not for diagnostic or therapeutic use!

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