DDIT3 Mouse Monoclonal Antibody
No Size Price Availability  
AMM1649-11 50ul 1500.00 In Stock
AMM1649-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 1649
Isotype: IgG2a Kappa Swiss Prot: P35638
purity: Affinity purification
Background:
CHOP was identified as a C/EBP-homologous protein that inhibits C/EBP and LAP in a dominant-negative manner. CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase. Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death. Studies also found that CHOP mediates the activation of GADD34 and Ero1-Lα expression during ER stress. GADD34 in turn dephosphorylates phospho-Ser51 of eIF2α thereby stimulating protein synthesis. Ero1-Lα promotes oxidative stress inside the endoplasmic reticulum (ER). The role of CHOP in the programmed cell death of ER-stressed cells is correlated with its role promoting protein synthesis and oxidative stress inside the ER.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 27 kDa
Recommended Dilutions
Immunogen DDIT3 (AAH036371, 94 aa ~ 155 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym CEBPZ, CHOP, CHOP10, GADD153, MGC4154
This product is for research use only, not for diagnostic or therapeutic use!

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