FAS Mouse Monoclonal Antibody
No Size Price Availability  
AMM355-12 50ul 1500.00 In Stock
AMM355-12 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 355
Isotype: IgG1 Kappa Swiss Prot: P25445
purity: Affinity purification
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Reactivity Human
Tested applications WB S-ELISA ELISA
Clonality Monoclonal Antibody
Calculated MW 37.7 kDa
Recommended Dilutions
Immunogen FAS (NP_000034, 20 aa ~ 119 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
This product is for research use only, not for diagnostic or therapeutic use!

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