GSK3B Mouse Monoclonal Antibody
No Size Price Availability  
AMM2932-61 50ul 1500.00 In Stock
AMM2932-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 2932
Isotype: IgG1 Swiss Prot: P49841
purity: Affinity chromatography
Background:
Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3beta, S6K, RSK, PKA and PKC), dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta-catenin, axin, CK1 and the APC complex).
Reactivity Human, Monkey, Mouse, Rat
Tested applications WB IHC ELISA ICC FC
Clonality Monoclonal Antibody
Calculated MW 46 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
FC 1:200-1:400
Immunogen A purified recombinant fragment of human GSK3B expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym GSK-3beta, GSK3-beta
This product is for research use only, not for diagnostic or therapeutic use!

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