| No | Size | Price | Availability | |
| AMM29760-61 | 50ul | 1500.00 | In Stock |  |
| AMM29760-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 29760 |
| Isotype: | IgG1 | Swiss Prot: | Q8WV28 |
| purity: | Affinity chromatography |
| Background: |
| This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC ELISA ICC FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 68 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human BLNK expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051 |
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