ER Mouse Monoclonal Antibody
No Size Price Availability  
AMM2099-62 50ul 1500.00 In Stock
AMM2099-62 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 2099
Isotype: IgG1 Swiss Prot: P03372
purity: Affinity chromatography
Background:
ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 66 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen A purified recombinant fragment of human ER expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym ER, ESR, Era, ESRA, NR3A1, DKFZp686N23123, ESR1
This product is for research use only, not for diagnostic or therapeutic use!

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