| No | Size | Price | Availability | |
| AMM5602-61 | 50ul | 1500.00 | In Stock |  |
| AMM5602-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 5602 |
| Isotype: | IgG1 | Swiss Prot: | P53779 |
| purity: | Affinity chromatography |
| Background: |
| The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Reactivity | Human, Mouse |
| Tested applications | WB ELISA ICC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 53 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human MAPK10 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EC 2.7.11.24, JNK3-alpha-2, JNK3A, MAP kinase p49 3F12, MAPK10, MK10, Mitogen-activated protein kinase 10, PRKM10, SAPK-beta, SERK2, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, kinase JNK3, p54- beta |
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