| No | Size | Price | Availability | |
| AMM5925-61 | 50ul | 1500.00 | In Stock |  |
| AMM5925-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 5925 |
| Isotype: | IgG1 | Swiss Prot: | P06400 |
| purity: | Affinity chromatography |
| Background: |
| The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb). |
| Reactivity | Human |
| Tested applications | IHC ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 106 kDa |
| Recommended Dilutions |
IHC 1:200-1:1000
|
| Immunogen | A purified recombinant fragment of human RB expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | RB, pRb, OSRC, pp110, p105-Rb, RB1 |
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