p53 Mouse Monoclonal Antibody
No Size Price Availability  
AMM7157-61 50ul 1500.00 In Stock
AMM7157-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 7157
Isotype: IgG1 Swiss Prot: P04637
purity: Affinity chromatography
Background:
p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Reactivity Human
Tested applications WB IHC ELISA
Clonality Monoclonal Antibody
Calculated MW 44 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:200-1:1000
Immunogen A purified recombinant fragment of human p53 expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym LFS1, TRP53, TP53
This product is for research use only, not for diagnostic or therapeutic use!

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