| No | Size | Price | Availability | |
| AMM9131-61 | 50ul | 1500.00 | In Stock |  |
| AMM9131-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 9131 |
| Isotype: | IgG1 | Swiss Prot: | O95831 |
| purity: | Affinity chromatography |
| Background: |
| This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10 |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IHC ELISA ICC FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 67 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human AIF expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AIFM1, AIF, PDCD8, COXPD6, MGC111425 |
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