Source: | Mouse | Gene Id: | 1029 |
Isotype: | IgG1 Kappa | Swiss Prot: | P42771 |
purity: | Affinity purification |
Background: |
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq |
Reactivity | Human |
Tested applications | WB IHC ELISA |
Clonality | Monoclonal Antibody |
Calculated MW | 16 kDa |
Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
|
Immunogen | A purified recombinant fragment of human CDKN2A expressed in E. Coli |
Storage | Store at 4°C in PBS, pH 7.4 (protein base, sodium azide). |
Synonym | CDKN4, KIP1, MEN1B, MEN4, P27KIP1 |
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