| No | Size | Price | Availability | |
| AMM207-62 | 50ul | 1500.00 | In Stock |  |
| AMM207-62 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 207/208/10000 |
| Isotype: | IgG1 | Swiss Prot: | P31749/P31751/Q9Y243 |
| purity: | Affinity chromatography |
| Background: |
| The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
| Reactivity | Human, Monkey, Mouse |
| Tested applications | WB ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 56 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A purified recombinant fragment of human AKT1 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EC 2.7.11.1RAC-PK-alphaProtein kinase BPKBC-AKT/EC 2.7.11.1RAC-PK-betaProtein kinase Akt-2Protein kinase B, betaPKB beta/EC 2.7.11.1RAC-PK-gammaProtein kinase Akt-3Protein kinase B, gammaPKB gammaSTK-2 |
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