| No | Size | Price | Availability | |
| AMM355-61 | 50ul | 1500.00 | In Stock |  |
| AMM355-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 355 |
| Isotype: | IgG1 | Swiss Prot: | P25445 |
| purity: | Affinity chromatography |
| Background: |
| The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
| Reactivity | human |
| Tested applications | WB ELISA ICC FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 38 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
ICC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human FAS expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Apo-1, CD95, FasL receptor, TNFRSF6, TNR6, apoptosis-mediating surface antigen FAS, tumor necrosis factor receptor superfamily member 6 |
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