PPM1A Mouse Monoclonal Antibody
No Size Price Availability  
AMM5494-61 50ul 1500.00 In Stock
AMM5494-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 5494
Isotype: IgG1 Swiss Prot: P35813
purity: Affinity chromatography
Background:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Reactivity Human, Monkey
Tested applications WB ELISA FC
Clonality Monoclonal Antibody
Calculated MW 42 kDa
Recommended Dilutions
WB 1:500-1:2000
FC 1:200-1:400
Immunogen A purified recombinant fragment of human PPM1A expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym PP2CA, PP2Calpha, PP2C-ALPHA
This product is for research use only, not for diagnostic or therapeutic use!

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