Source: | Mouse | Gene Id: | 4041 |
Isotype: | IgG1 | Swiss Prot: | O75197 |
purity: | Affinity chromatography |
Background: |
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. |
Reactivity | Human |
Tested applications | WB ELISA FC |
Clonality | Monoclonal Antibody |
Calculated MW | 179 kDa |
Recommended Dilutions |
WB 1:500-1:2000
FC 1:200-1:400
|
Immunogen | A purified recombinant fragment of human LRP5 expressed in E. Coli |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, OPTA1, VBCH2 |
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