NGFR Mouse Monoclonal Antibody
No Size Price Availability  
AMM4804-61 50ul 1500.00 In Stock
AMM4804-61 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 4804
Isotype: IgG Swiss Prot: P08138
purity: Affinity purification
Background:
The p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligand-binding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain (1). p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal neurons (2).The p75NTR protein undergoes sequential cleavage similar to APP and Notch. First, α-secretase removes the p75NTR ectodomain, eliminating ligand-mediated signaling. At this point, the membrane-tethered cleavage product can still fine-tune Trk-mediated trophic actions. γ-secretase cleaves within the transmembrane domain to liberate the cytoplasmic tail from its membrane anchor and allow the p75NTR intracellular domain to translocate to the nucleus (3,4).
Reactivity Human
Tested applications WB ELISA ICC FC
Clonality Monoclonal Antibody
Calculated MW 45 kDa
Recommended Dilutions
WB 1:500-1:2000
ICC 1:200-1:1000
FC 1:200-1:400
Immunogen A purified recombinant fragment of human NGFR expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR
This product is for research use only, not for diagnostic or therapeutic use!

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