MYC Mouse Monoclonal Antibody
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AMM4609-61 50ul 1500.00 In Stock
AMM4609-61 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 4609
Isotype: IgG Swiss Prot: P01106
purity: Affinity purification
Background:
Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis (1). These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with MYC and found to be required for the ability of Myc to bind DNA and activate transcription (2). Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families (1). The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior (1). The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription (3,4).
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 49 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen A purified recombinant fragment of human MYC expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym MYC, MRTL, bHLHe39, c-Myc, Myc proto-oncogene protein, Proto-oncogene c-Myc, Transcription factor p64
This product is for research use only, not for diagnostic or therapeutic use!

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