MPL Mouse Monoclonal Antibody
No Size Price Availability  
AMM4352-61 50ul 1500.00 In Stock
AMM4352-61 100ul 2000.00 In Stock
  • Details
  • FAQs
  • Manual
Source: Mouse Gene Id: 4352
Isotype: IgG1 Swiss Prot: P40238
purity: Affinity chromatography
Background:
n 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Reactivity Human
Tested applications WB ELISA FC
Clonality Monoclonal Antibody
Calculated MW 71 kDa
Recommended Dilutions
WB 1:500-1:2000
FC 1:200-1:400
Immunogen A purified recombinant fragment of human MPL expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym MPLV, TPOR, C-MPL, CD110
This product is for research use only, not for diagnostic or therapeutic use!

backtop
QQ
service center
Contact Us