| No | Size | Price | Availability | |
| AMM1869-61 | 50ul | 1500.00 | In Stock |  |
| AMM1869-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 1869 |
| Isotype: | IgG1 | Swiss Prot: | Q01094 |
| purity: | Affinity chromatography |
| Background: |
| The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq] |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC ELISA FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 47 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human E2F1 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | E2F-1, PBR3, PRB-binding protein E2F-1, RBAP-1, RBBP-3, RBBP3, Retinoblastoma binding protein 3, Retinoblastoma-associated protein 1, Transcription factor E2F1 |
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