VAV1 Mouse Monoclonal Antibody
No Size Price Availability  
AMM7409-61 50ul 1500.00 In Stock
AMM7409-61 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 7409
Isotype: IgG Swiss Prot: P15498
purity: Affinity purification
Background:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Reactivity Human
Tested applications WB ELISA FC
Clonality Monoclonal Antibody
Calculated MW 98 kDa
Recommended Dilutions
WB 1:500-1:2000
FC 1:200-1:400
Immunogen A purified recombinant fragment of human VAV1 expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym VAV
This product is for research use only, not for diagnostic or therapeutic use!

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