4E-BP1 Mouse Monoclonal Antibody
No Size Price Availability  
AMM1978-61 50ul 1500.00 In Stock
AMM1978-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 1978
Isotype: IgG1 Swiss Prot: Q13541
purity: Affinity chromatography
Background:
4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Reactivity Human
Tested applications WB IHC ELISA
Clonality Monoclonal Antibody
Calculated MW 12 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:200-1:1000
Immunogen A purified recombinant fragment of human 4E-BP1 expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym BP-1, 4EBP1, 4E-BP1, PHAS-I, MGC4316, EIF4EBP1
This product is for research use only, not for diagnostic or therapeutic use!

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