ATM Mouse Monoclonal Antibody
No Size Price Availability  
AMM472-61 50ul 1500.00 In Stock
AMM472-61 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 472
Isotype: IgG1 Swiss Prot: Q13315
purity: Affinity chromatography
Background:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. At least three alternatively spliced transcript variants, which encode distinct isoforms, have been identified.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 351 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen A purified recombinant fragment of human ATM expressed in E. Coli
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym A-T, mutated, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated homolog, EC 2.7.11.1, kinase ATM, Serine-protein kinase ATM
This product is for research use only, not for diagnostic or therapeutic use!

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