| No | Size | Price | Availability | |
| AMM1576-61 | 50ul | 1500.00 | In Stock |  |
| AMM1576-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 1576 |
| Isotype: | IgG1 | Swiss Prot: | P08684 |
| purity: | Affinity chromatography |
| Background: |
| This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. |
| Reactivity | Human |
| Tested applications | WB IHC ELISA ICC FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 57 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human CYP3A4 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Cytochrome P450 3A4, EC 1.14.13.67, Quinine 3-monooxygenase, CYPIIIA4, Nifedipine oxidase, Nifedipine oxidase, Cytochrome P450 3A3, CYPIIIA3, HLp, Taurochenodeoxycholate 6-alpha-hydroxylase, EC 1.14.13.97, NF-25, P450-PCN1, CYP3A3, CP3A4 |
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