| No | Size | Price | Availability | |
| AMM112939-61 | 50ul | 1500.00 | In Stock |  |
| AMM112939-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 112939 |
| Isotype: | IgG1 | Swiss Prot: | Q96RE7 |
| purity: | Affinity chromatography |
| Background: |
| NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . |
| Reactivity | Human |
| Tested applications | WB IHC ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 58 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
|
| Immunogen | A purified recombinant fragment of human NACC1 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | NAC1, BEND8, NAC-1, BTBD14B, FLJ37383, NACC1 |
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