| No | Size | Price | Availability | |
| AMM5894-61 | 50ul | 1500.00 | In Stock |  |
| AMM5894-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 5894 |
| Isotype: | IgG1 | Swiss Prot: | P04049 |
| purity: | Affinity chromatography |
| Background: |
| Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. |
| Reactivity | Human |
| Tested applications | WB IHC ELISA FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 72 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human RAF1 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | C-RAF, C-Raf, CRAF, EC 2.7.11.1, Protein kinase raf 1, RAF proto-oncogene serine/threonine-protein kinase, RAF-1, RAF1, Raf proto-oncogene serine/threonine-protein kinase, Raf-1, Similar to murine leukemia viral (V-raf-1) oncogene homolog 1, kinase Raf1 |
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