| No | Size | Price | Availability | |
| AMM1020-61 | 50ul | 1500.00 | In Stock |  |
| AMM1020-61 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 1020 |
| Isotype: | IgG1 | Swiss Prot: | Q00535 |
| purity: | Affinity chromatography |
| Background: |
| CDK5 is a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity. |
| Reactivity | Human, Monkey, Rat |
| Tested applications | WB IHC ELISA ICC FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 35 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:200-1:1000
ICC 1:200-1:1000
FC 1:200-1:400
|
| Immunogen | A purified recombinant fragment of human CDK5 expressed in E. Coli |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CDK5, CRK6, Cell division protein kinase 5, EC 2.7.11.22, PSSALRE, TAU protein kinase II catalytic subunit, TPKII catalytic subunit, Tau protein kinase II catalytic subunit, kinase Cdk5 |
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