| No | Size | Price | Availability | |
| YMM02011-01 | 50ul | 1500.00 | In Stock |  |
| YMM02011-01 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 5111 |
| Isotype: | IgG | Swiss Prot: | P12004 |
| purity: | Purified by Protein G. |
| Background: |
| Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. |
| Reactivity | Human, Rat, Rabbit |
| Tested applications | WB IHC IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human PCNA |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | ATLD2, Proliferating cell nuclear antigen, PCNA, Cyclin |
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