Phospho-Rad17 (Ser645) Rabbit Polyclonal Antibody
No Size Price Availability  
YRP03375P-01 50ul 1500.00 In Stock
YRP03375P-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5884
Isotype: IgG Swiss Prot:
purity: Purified by Protein A.
Background:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic phosphopeptide derived from human Rad17 around the phosphorylation site of Ser645
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym CCYC, Cell cycle checkpoint protein, Cell cycle checkpoint protein RAD17, HRAD 17, HRAD17, R24L, Rad 17, Rad 24, RAD1 S. pombe homolog, RAD17 homolog, Rad17 like protein, RAD17Sp, Rad24, RF C activator 1 homolog, RF C/activator 1 homolog.
This product is for research use only, not for diagnostic or therapeutic use!

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