Phospho-Progesterone Receptor(Ser190) Rabbit Polyclonal Antibody
No Size Price Availability  
YRP03361P-01 50ul 1500.00 In Stock
YRP03361P-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5241
Isotype: IgG Swiss Prot:
purity: Purified by Protein A.
Background:
Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.
Reactivity Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic phosphopeptide derived from rat Progesterone Receptor around the phosphorylation site of Ser190
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym PGRphospho S190, NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, PRGR_RAT.
This product is for research use only, not for diagnostic or therapeutic use!

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