| No | Size | Price | Availability | |
| YRP00462P-01 | 50ul | 1500.00 | In Stock |  |
| YRP00462P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4087 |
| Isotype: | IgG | Swiss Prot: | Q15796 |
| purity: | Purified by Protein A. |
| Background: |
| Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human SMAD2 around the phosphorylation site of Ser465 |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, Mad-related protein 2, SMAD family member 2, SMAD 2, Smad2 |
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