| No | Size | Price | Availability | |
| YRP13245-01 | 50ul | 1500.00 | In Stock |  |
| YRP13245-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 51343 |
| Isotype: | IgG | Swiss Prot: | Q9UM11 |
| purity: | Purified by Protein A. |
| Background: |
| Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human FZR1/CDC20C |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, FZR1, FYR, KIAA1242 |
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