MYLK Rabbit Polyclonal Antibody
No Size Price Availability  
ARP4638-01 50ul 1500.00 In Stock
ARP4638-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 4638
Isotype: IgG Swiss Prot: Q15746
purity: Affinity purification
Background:
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
Reactivity Human
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 211kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen Recombinant protein of human MYLK
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym KRP, AAT7, MLCK, MLCK1, MYLK1, smMLCK, MLCK108, MLCK210, MSTP083
This product is for research use only, not for diagnostic or therapeutic use!

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