| No | Size | Price | Availability | |
| ARP142-02 | 50ul | 1500.00 | In Stock |  |
| ARP142-02 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 142 |
| Isotype: | IgG | Swiss Prot: | P09874 |
| purity: | Affinity purification |
| Background: |
| PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6). |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 113kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:100
|
| Immunogen | A synthetic peptide of human PARP1 |
| Storage | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | ADPRT, ADPRT1, PARP, PARP-1, PPOL, pADPRT-1 |
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