ARP142-02
[Polyclonal Antibody]
PARP1 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC IF |
| Immunogen Range: | A synthetic peptide of human PARP1 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 142 |
| Swiss Prot: | P09874 |
| Synonyms: | ADPRT, ADPRT1, PARP, PARP-1, PPOL, pADPRT-1 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Background: | PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6). |
| Caculated MW: | 113kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:100 |
| Reacitivity: | Human, Mouse |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
