APITD1 Rabbit Polyclonal Antibody
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ARP378708-01 50ul 1500.00 In Stock
ARP378708-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 378708
Isotype: IgG Swiss Prot: Q8N2Z9
purity: Affinity purification
Background:
This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]
Reactivity Human
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 16 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen Recombinant protein of human APITD1
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym MHF1, CENPS, CENP-S, FAAP16
This product is for research use only, not for diagnostic or therapeutic use!

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