| No | Size | Price | Availability | |
| ARP7178P-21 | 50ul | 1500.00 | In Stock |  |
| ARP7178P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7178 |
| Isotype: | / | Swiss Prot: | P13693 |
| purity: | Affinity purification |
| Background: |
| Translationally controlled tumor protein (TCTP/p23/HRF) is a ubiquitously expressed and highly conserved protein involved in various cellular processes, such as its role as a histamine releasing factor in chronic allergic disease (1). TCTP binds tubulin in a cell cycle dependent manner and is associated with the mitotic spindle (2). In addition, TCTP interacts with the actin cytoskeleton to regulate cell shape (3). In mitosis, TCTP is phosphorylated by PLK at Ser46, decreasing microtubule stability (4,5). TCTP interacts with the small GTPase Rheb, possibly acting as a GEF, thereby activating the TORC1 pathway and controlling cell growth and proliferation (6,7). TCTP has also been shown to be involved in apoptosis and cell stress (8-11). In cultured cells, reduction in TCTP expression can cause loss of the malignant phenotype (12). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IHC IF FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 23 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:100
IF 1:200
FC 1:100
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser46 of human TCTP protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | HRF, p02, p23, TCTP |
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