| No | Size | Price | Availability | |
| ARP2029P-21 | 50ul | 1500.00 | In Stock |  |
| ARP2029P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2029 |
| Isotype: | / | Swiss Prot: | O43768 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Reactivity | Human, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 15 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Ser67/Ser62 of human ENSA/ARPP19 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | MGC4319, MGC78563, MGC8394 |
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