| No | Size | Price | Availability | |
| ARP8626P-21 | 50ul | 1500.00 | In Stock |  |
| ARP8626P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8626 |
| Isotype: | / | Swiss Prot: | Q9H3D4 |
| purity: | Affinity purification |
| Background: |
| The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function (2). While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors (2). Research investigators frequently observe amplification of the p63 gene in squamous cell carcinomas of the lung, head and neck (2,3). The p63 gene contains an alternative transcription initiation site that yields a 40 kDa δNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the α, β, and γ isoforms (3,4).TAp63-alpha (full-length) contains multiple serine residues followed by proline (Ser-Pro motif) that are potential cdk substrates expected to be phosphorylated in mitosis. Among these are Ser160, Ser162, Ser395, and Ser455. |
| Reactivity | Human |
| Tested applications | WB IHC FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 75 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:150
FC 1:25
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser160/160 of human TAp63-alpha |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L |
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