| No | Size | Price | Availability | |
| ARP7137P-21 | 50ul | 1500.00 | In Stock |  |
| ARP7137P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7137 |
| Isotype: | / | Swiss Prot: | P19429 |
| purity: | Affinity purification |
| Background: |
| Troponin, working in conjunction with tropomyosin, functions as a molecular switch that regulates muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI) (1). In response to β-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC (1-3). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 28 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser23/24 of human troponin I (cardiac) |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI |
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