| No | Size | Price | Availability | |
| ARP11284P-21 | 50ul | 1500.00 | In Stock |  |
| ARP11284P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 11284 |
| Isotype: | / | Swiss Prot: | Q96T60 |
| purity: | Affinity purification |
| Background: |
| PNK (polynucleotide kinase) is a DNA repair enzyme that participates in single strand break repair and non-homologous end rejoining (NHEJ) for double strand breaks. PNK possesses a 5'-DNA kinase activity and a 3'-DNA phosphatase activity (1,2). It has three domains, a C-terminal kinase domain, a central phosphatase domain, and an N-terminal forkhead associated (FHA) domain that is responsible for protein-protein interactions. Reduction in expression of PNK by RNAi sensitizes cells to ionizing radiation and topoisomerase I inhibitors (3) |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 59 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues around Ser114 and Thr118 of human PNK1 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | PNK |
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