| No | Size | Price | Availability | |
| ARP3872P-21 | 50ul | 1500.00 | In Stock |  |
| ARP3872P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3872 |
| Isotype: | / | Swiss Prot: | Q04695 |
| purity: | Affinity purification |
| Background: |
| Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).Keratin 17 has been shown to be involved in wound healing, a process that requires rapid remodelling of the cytoskeleton (7). Another process that requires cytoskeletal remodelling is cell growth. It has been shown that in keratin 17 null keratinocytes that signaling through the Akt/mTOR pathway fails to produce an increase in translation, cell size or growth, and that this defect is associated with abnormal localization of 14-3-3σ. Since in normal cells, 14-3-3σ associates with keratin 17, a model has been proposed whereby signaling through Akt/mTOR produces a sequestration of 14-3-3σ in the cytosol via its interaction with keratin 17, and this sequestration by keratin 17 is required for translation and cell growth. Phosphorylation of keratin 17 on Ser 44 is thought to provide a docking site for 14-3-3σ binding (8). |
| Reactivity | Human |
| Tested applications | WB FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 49 kDa |
| Recommended Dilutions |
WB 1:1000
FC 1:50
|
| Immunogen | A synthetic phosphopeptide corresponding to amino acids surrounding Ser44 of human keratin 17 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | K17, PC, PC2, PCHC1 |
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