| No | Size | Price | Availability | |
| ARP4040P-21 | 50ul | 1500.00 | In Stock |  |
| ARP4040P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4040 |
| Isotype: | / | Swiss Prot: | O75581 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. |
| Reactivity | Human |
| Tested applications | WB IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 180, 210 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser1490 of human LRP6 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ADCAD2 |
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