| No | Size | Price | Availability | |
| ARP5243-11 | 50ul | 1500.00 | In Stock |  |
| ARP5243-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5243 |
| Isotype: | / | Swiss Prot: | P08183 |
| purity: | Affinity purification |
| Background: |
| The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq |
| Reactivity | Dog, Human, Monkey, Mouse, Rat |
| Tested applications | WB ELISA |
| Clonality | Polyclonal Antibody |
| Calculated MW | 180 kDa |
| Recommended Dilutions |
WB 1:200-1:2000
|
| Immunogen | A synthetic peptide corresponding to amino acids 262-277 of human ABCB1 |
| Storage | Store at 4°C. For long term storage store at -20°C in 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1 |
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