| No | Size | Price | Availability | |
| ARP545-11 | 50ul | 1500.00 | In Stock |  |
| ARP545-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 545 |
| Isotype: | / | Swiss Prot: | Q13535 |
| purity: | Affinity purification |
| Background: |
| Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are PI3 kinase-related kinase (PIKK) family members that phosphorylate multiple substrates on serine or threonine residues that are followed by a glutamine in response to DNA damage or replication blocks (1-3). Despite the essential role of ATR in cell cycle signaling and DNA repair processes, little is known about its activation. Phosphorylation of ATR at serine 428 in response to UV-induced DNA damage has been suggested as a means of activating ATR (4,5). Threonine 1989 was also recently identified as a potential marker of activated ATR (6,7). |
| Reactivity | Dog, Human, Monkey, Mouse, Rat, Xenopus |
| Tested applications | WB ELISA |
| Clonality | Polyclonal Antibody |
| Calculated MW | 300 kDa |
| Recommended Dilutions |
WB 1:1000-1:5000
|
| Immunogen | A synthetic peptide corresponding to amino acids 262-277 of human ATR |
| Storage | Store at 4°C. For long term storage store at -20°C in 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | FRP1, MEC1, SCKL, SCKL1 |
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