| No | Size | Price | Availability | |
| ARP6502-11 | 50ul | 1500.00 | In Stock |  |
| ARP6502-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6502 |
| Isotype: | / | Swiss Prot: | Q13309 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms. [provided by RefSeq |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 48 kDa |
| Recommended Dilutions |
WB 1 ug/mL
IHC 1-2 ug/mL
ICC 1-2 ug/mL
|
| Immunogen | A synthetic peptide corresponding to amino acids at N-terminus of human SKP2 |
| Storage | Store at -20°C on dry atmosphere. |
| Synonym | FBL1, FBXL1, FLB1, MGC1366 |
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