| No | Size | Price | Availability | |
| ARP1452-11 | 50ul | 1500.00 | In Stock |  |
| ARP1452-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1452 |
| Isotype: | / | Swiss Prot: | P48729 |
| purity: | Protein G purification |
| Background: |
| Casein Kinase I (CK1 or CKI) is the name given to a family of kinases consisting of multiple isoforms (α, α', β, γ1-3, δ, and ε) with a conserved N-terminal kinase domain and a variable C-terminal sequence that determines subcellular localization and regulates enzyme activity (1-3). Indeed, multiple inhibitory autophosphorylation sites have been identified near the C terminus of CK1ε (3). This ubiquitously expressed family of protein kinases has been implicated in multiple processes including DNA repair, cell morphology, and Wnt signaling (4). Perhaps the best understood role of CK1 is to provide the priming phosphorylation of β-catenin at Ser45 to produce the consensus GSK-3 substrate motif (S/T-X-X-X-pS) (4). |
| Reactivity | Human |
| Tested applications | WB IHC ELISA |
| Clonality | Polyclonal Antibody |
| Calculated MW | 34 kDa |
| Recommended Dilutions |
WB 1:100-1:500
IHC 1:10-1:50
|
| Immunogen | A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CSNK1A1 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | CK1, HLCDGP1, PRO2975 |
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