| No | Size | Price | Availability | |
| ARP9968-12 | 50ul | 1500.00 | In Stock |  |
| ARP9968-12 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9968 |
| Isotype: | IgG | Swiss Prot: | Q93074 |
| purity: | Antigen affinity purification |
| Background: |
| The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq |
| Reactivity | Human |
| Tested applications | IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 240 kDa |
| Recommended Dilutions |
IHC 1:20-1:50
IF 1-4 ug/mL
|
| Immunogen | A recombinant protein corresponding to amino acids of human MED12 |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | CAGH45, FGS1, HOPA, KIAA0192, OKS, OPA1, TNRC11, TRAP230 |
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