| No | Size | Price | Availability | |
| ARP3572-11 | 50ul | 1500.00 | In Stock |  |
| ARP3572-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3572 |
| Isotype: | / | Swiss Prot: | P40189 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC ELISA |
| Clonality | Polyclonal Antibody |
| Calculated MW | 130 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:100
|
| Immunogen | A synthetic peptide corresponding to residues surrounding S782 of human IL6ST |
| Storage | Store at -20°C in PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | CD130, CDw130, GP130, GP130-RAPS, IL6R-beta |
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